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-synuclein, that's a most important element of Lewy bodies, in PARK one in 1997 and parkin in PARK two in 1998, which happens to be an E3 ubiquitin ligase and leads to endoplasmic reticulum (ER) worry, advise that dysfunction on the intracellular proteinase devices, for instance ubiquitin-proteasome system or lysosomal system, which gets rid of avo

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